By Wojciech Gorczyca
This Atlas is a necessary advisor to either the prognosis and differential prognosis of neoplastic hematopathologies, according to particular parameters. will probably be a useful reference for all training hematologists, oncologists and pathologists. Atlas of Differential prognosis in Neoplastic Hematopathology, moment version discusses: uncomplicated scientific information prognostic facts morphologic information phenotypic information together with over six hundred colour illustrations, Atlas of Differential analysis in Neoplastic Hematopathology, moment variation is broadly referenced and up-to-date. overlaying neoplastic hematopathology, with an emphasis at the differential analysis, quite a few tables summarize the phenotypic profiles of the commonest hematologic tumors, for the practising hematologist, oncologist and pathologist. NEW TO the second one version: A multimethodologic method of neoplastic hematopathology New and considerably up to date sections on differential prognosis and morphology, chromosomal and genetic adjustments, and localization
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FLT3 c-KIT WT1 NPM1 + t(15;17) [PML/RARα] [PML/RARα]+ No CD4+,CD56+ (CD3-, CD34-) Yes Yes B-cell markers+ Abnormal cell population? g. g. g. 5 Hematopoietic tumors with negative CD45 expression (differential diagnosis). (A) Multiple myeloma. (B) Dendritic cell sarcoma. (C) ALCL. (D) Classical Hodgkin lymphoma. (E) Plasmablastic lymphoma. (F) B-ALL. (G) DLBCL (large B-cells are CD20+ and CD45− small T-cells are CD20− and CD45+). − +/− + − − − (rarely+) − − (rarely+) − − − − − DLBCL Lymphoplasmacytic lymphoma HCL MM + (bright) − −/+ +/− − − + + + + + + + + + CD19 −/+ + + + (rarely−) + + + + +(dim) + CD20 +/− − − − − −/+ +/− +/− + − CD23 − + − − −/+ −/+ − − −/+ − CD25 +/− − − − − − − (rarely+) −/+ − − CD30 + − −/+ + −/+ −/+ +/− − + + CD43 +/− + + + + + + + CD79a − + − (rarely+) − − (rarely+) − − − − − CD103 − (rarely+) −/+ − − − − − − − + Bcl-1 − − − + − +/− − + − − Bcl-6 5/23/2008 B-CLL/SLL, B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia; MCL, mantle cell lymphoma; B-PLL, B−prolymphocytic leukemia; FL, follicular lymphoma; DLBCL, diffuse large B-cell lymphoma; BL, Burkitt lymphoma; MZL, marginal zone B-cell lymphoma; HCL, hairy cell leukemia; MM, multiple myeloma.
HCL is positive for CD11c, CD25, annexin, DBA44, and CD103. DLBCL, apart from B-cell markers, may express CD10, bcl-2, bcl-6, CD30, CD43, and MUM1. Burkitt lymphoma typically expresses CD10, CD43, bcl-6, and Ki-67 (~100%), and is negative for bcl-2. 2 presents the typical phenotypic profiles for the major types of mature B-cell lymphoproliferations. 2; CK7; CK20) Keratin+ Benign (reactive) Cytogenetics/FISH for t(8;14)/MYC and BCL2 and/orBCL6 rearrangements CD19/CD20/PAX5+ surface κ or λ restriction GPHA+, hemoglobin A+ CD56+, keratin+ CD34+, TdT+, CD10± Non-hematopoietic tumor or benign?
43P) may indicate an aggressive or advanced multiple myeloma; plasma cell leukemia is characterized by a leukocyte differential with >20% plasma cells. 43Q). 43R) but can also be seen in other types of acute leukemias, including CD56+ AML. 42 Bone marrow – non-hematopoietic tumors (differential diagnosis). Breast carcinoma: (A) extensive marrow involvement; (B) scattered cancerous cells with typical intracytoplasmic vacuoles; (C) tumor cells in the background of extensive marrow fibrosis. (D) Prostate adenocarcinoma.
An Atlas of Differential Diagnosis in Neoplastic Hematopathology by Wojciech Gorczyca