By Shaker A. Mousa
1This choice of overview articles highlights the most recent improvement of antithrombotics and gives confirmed experimental equipment for the additional improvement of recent and more advantageous anticoagulants. one of the state of the art advancements reviewed are the unconventional utilization of low molecular weight heparins, such antithrombin brokers because the hirudin, and such antiplatelet medications because the GPIIb/IIIa inhibitors and ADP receptor antagonists. extra recommendations mentioned contain aspirin and clopidogrel, the accelerated use of polytherapeutic techniques, antiproteases (factors IIa, Xa, and VIIa), tissue issue focusing on, platelet receptor focusing on, and antithrombin III modulation.
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Extra info for Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine)
33, 141–164. CH03,21-34,14pgs 9/5/03 11:01 AM Page 33 In Vitro Flow Models of Thrombosis 33 5. Alevriadou, B. , Moake, J. , Turner, N. , Ruggeri, Z. , Folie, B. , Phillips, M. , et al. (1993) Real-time analysis of shear dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 81, 1263–1276. 6. Turitto, V. T. (1982) Blood viscosity, mass transport, and thrombogenesis. Prog. Hemostasis Thromb. 6, 139–177. 7. The EPIC Investigators (1994) Use of a monoclonal antibody directed against the glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty.
Degree of Sulfation Chemical modifications of the end groups and internal structure, degree of sulfation, and charge density vary from product to product, and affect the characteristics of the products. Depending on the method of preparation, the LMWHs are different mixtures of various polysaccharides, antifactor X (anti-Xa), anti-IIa activities, endothelial TFPI release, and different biologic actions (6,16). CH04,35-48,14pgs 42 9/5/03 11:01 AM Page 42 Mousa 4. Plasmatic Effects Heparin affects the coagulation cascade at multiple sites.
Materials 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Anticoagulant solution (sodium citrate, porcine heparin, PPACK). Fluorescently labeled platelet-specific antibody. Dulbecco’s phosphate-buffered saline (D-PBS) (with and without Ca2+/Mg2+). Formaldehyde. Type I collagen, from bovine Achille’s tendon. 5 mol/L glacial acetic acid in water. Glass cover slips (24 × 50 mm; Corning; Corning, NY). , Saginaw, MI). Quinacrine dihydrochloride. Prostaglandin E1 (PGE1) and EGTA. Thrombin. Bovine serum albumin (BSA).
Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Medicine) by Shaker A. Mousa