By L. Heilmeyer, H. Begemann, Helmut Löffler, Johann Rastetter, Torsten Haferlach
This sixth version of the atlas has built-in the 2001 WHO class and made use of figures and outlines to rfile lately defined kinds of leukemia and lymphoma. The latter comprise leukemias of dendritic cells, infrequent lymphomas and protracted polyclonal B lymphocytosis, which takes a different position within the classification.
The quantity covers the entire microscopic tools in hematology that shape the root of prognosis in addition to the result of sleek immunologic, cytogenetic and molecular-genetic research. particular emphasis is put on the cytogenetic and molecular-genetic characterization of organic entities that would shape the foundation for cutting edge therapies.
Normal effects and pathological findings are in comparison, and a few of the findings made in the course of remedy are depicted. All in the entire Atlas of medical Hematology represents an entire and worthwhile reference paintings which can be found in each hematologic and oncologic division in addition to in medical laboratories for on-line diagnostics and medical research.
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The abnormal granulation is especially marked in eosinophils, which appear basophilic rather than eosinophilic (Fig. 10 e, left). The lymphocytes also contain particularly large azurophilic granules (Fig. 10 f). Carriers of this anomaly frequently have associated bone and joint deformities (gargoylism). The anomaly is known to occur in mucopolysaccharidosis VI and VII. 47 4 · Individual Cells Fig. 10 a – d a b c d IV 48 Chapter IV · Blood and Bone Marrow Fig. 10 e – f IV e f 49 4 · Individual Cells Steinbrinck-Chediak-Higashi Anomaly (Granular Gigantism of Leukocytes) (Fig.
12 a – d) IV This disorder has an autosomal dominant mode of inheritance and is associated with mild leukopenia and thrombocytopenia. The neutrophilic granulocytes contain predominantly rod-shaped inclusions of a pale- to dirty-blue color, approximately 2 – 5 lm in diameter, which are found on electron microscopy to consist of dense RNA fibrils and are distinguishable from the Do¨hle bodies that occur in severe infections. The inclusions also occur in monocytes and eosinophils, but they are very difficult to detect in these cells.
Affected individuals usually die at an early age. IV 50 Chapter IV · Blood and Bone Marrow Fig. 11 a – d IV a b c d 51 4 · Individual Cells Fig. 11 e – f e f IV 52 Chapter IV · Blood and Bone Marrow May-Hegglin Anomaly (Fig. 12 a – d) IV This disorder has an autosomal dominant mode of inheritance and is associated with mild leukopenia and thrombocytopenia. The neutrophilic granulocytes contain predominantly rod-shaped inclusions of a pale- to dirty-blue color, approximately 2 – 5 lm in diameter, which are found on electron microscopy to consist of dense RNA fibrils and are distinguishable from the Do¨hle bodies that occur in severe infections.
Atlas of Clinical Hematology by L. Heilmeyer, H. Begemann, Helmut Löffler, Johann Rastetter, Torsten Haferlach