Basic Science of Oncology by Ian Tannock, Richard Hill, Robert Bristow, Lea Harrington PDF

By Ian Tannock, Richard Hill, Robert Bristow, Lea Harrington

ISBN-10: 0071745203

ISBN-13: 9780071745208

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Results were visualized using Tree View software, and include the dendrogram (clustering of samples) and the clustering of gene expression, based on genomic similarity. Tree View represents the 946 genes that best distinguish these 2 groups of samples. Genes whose expression is higher in the tumor sample relative to the reference sample are shown in red; those whose expression is lower than the reference sample are shown in green; and no change in gene expression is shown in black. ) 22 CHAPTER 2 Me C g C g g C The two main components of the epigenetic code Me DNA methylation Methyl marks added to certain DNA bases repress gene activity.

Virus can then be transduced into a wide range of cell types, including both dividing and nondividing mammalian cells. Note that the packaging mix is often separated into multiple plasmids, minimizing the threat of recombinant replication-competent virus production. Viral titers are measured in either transduction units (TU)/mL or multiplicity of infection (MOI), which is the number of transducing lentiviral particles per cell to which the following relationship applies under experimental conditions: (Total number of cells per well) × (Desired MOI) = Total TU needed (Total TU needed)/(TU/mL reported on certificate of authentication) = Total mL of lentiviral particles to add to each well (utilizing magnetic forces to drive nucleic acid particle complexes into the target cell), and impalefection (impaling cells by elongated nanostructures such as carbon nanofibers or silicon nanowires which have been coated with plasmid DNA) are becoming less popular given the greater efficiency of viral transfection.

This technique can reveal the methylation status of every cytosine residue, and it is amenable to massively parallel sequencing methods. Affinity-based methods using methyl-specific Methods of Molecular Analysis 23 TABLE 2–3 Methods for analyzing DNA methylation. Method Description Advantages Disadvantages Sodium bisulfite conversion Treatment of denatured DNA (ie, single-stranded DNA) with sodium bisulfite leads to deamination of unmethylated cytosine residues to uracil, leaving 5-mC intact. The uracils are amplified as thymines, and 5-mC residues are amplified as cytosines in PCRs.

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Basic Science of Oncology by Ian Tannock, Richard Hill, Robert Bristow, Lea Harrington

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