Read e-book online Biologic Therapy of Leukemia (Contemporary Hematology) PDF

By Matt Kalaycio

ISBN-10: 1588290719

ISBN-13: 9781588290717

ISBN-10: 1592593836

ISBN-13: 9781592593835

Fascinating new "biologic" treatments for treating leukemia are showing so swiftly that clinicians usually locate it tough to make educated judgements approximately their use while making sufferer therapy judgements. Biologic treatment of Leukemia summarizes and studies the entire to be had information touching on those state-of-the-art biologic remedies in order that working towards clinicians could make the proper patient-care offerings. right here the busy healthcare professional will locate in a single handy position an important info at the makes use of and boundaries of the most important biologic cures for leukemia, the various biologic techniques for its remedy, the administration of sufferers being handled with such biologic brokers, and the present and destiny position of rising biologic brokers.

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Additional resources for Biologic Therapy of Leukemia (Contemporary Hematology)

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Doney K, Fisher L, Appelbaum F, et al. Treatment of adult acute lymphoblastic leukemia with allogeneic bone marrow transplantation. Multivariate analysis of factors affecting acute graftversus-host disease, relapse, and relapse-free survival. Bone Marrow Trans 1991;7:453–459. 12. Passweg J, Tiberghien P, Cahn J, et al. Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia. Bone Marrow Trans 1998;21:153–158. 13. Uzunel M, Mattsson J, Jaksch M, Remberger M, Ringdén O.

Sullivan K, Weiden P, Storb R, et al. Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. Blood 1989;73:1720–1728. 7. Horowitz M, Gale R, Sondel P, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990;75:555–562. 8. Jones R, Ambinder R, Piantadosi S, Santos G. Evidence of graft-versus-lymphoma effect associated with allogeneic bone marrow transplantation.

Most B-cell lymphoproliferative disorders have high-level CD20 expression, but the function of CD20 is unknown. Rituximab is a chimeric anti-CD20 MAb that induces cytotoxicity when bound to surface CD20. Several potential mechanisms of action may explain rituximab’s therapeutic activity, including ADCC, complement-mediated cytotoxicity, and apoptosis induction (14–17) Rituximab administered as single agent at a dose of 375 mg/m2 weekly for 4 wk results in an approx 50% response rate in relapsed low-grade non-Hodgkin’s lymphoma (18).

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Biologic Therapy of Leukemia (Contemporary Hematology) by Matt Kalaycio


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