By James S. Malpas MD DPhil FRCP FRCR FRCPCH, Daniel E. Bergsagel CM MD DPhil, Robert A. Kyle MD, Kenneth C. Anderson MD
Bone marrow-based malignancy is changing into extra standard. There have additionally been significant advances within the prognosis, pathogenesis, and remedy of this universal tumor style. In Biology and administration of a number of Myeloma, professional physicians and scientific researchers summarize and clarify the new advances within the biology and remedy of this universal B-cell tumor. at the organic facet, the authors evaluate the numerous very important, clinically correct discoveries which were made within the previous few years. They exhibit the features of the malignant mobile and describe the numerous roles performed by way of oncogenic alterations, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic components also are analyzed. at the scientific aspect, the authors offer a entire assessment of traditional therapy regimens, in addition to a dialogue of more recent experimental methods related to immunologic focusing on, inhibitors of drug resistance, and antitumor brokers. The function of high-dose remedy is usually mentioned, besides the therapy of such problems as renal affliction, anemia, and bone ailment.
finished and authoritative, Biology and administration of a number of Myeloma deals either clinicians and researchers a completely updated figuring out of the recent biology that may be without delay utilized not just to destiny laboratory reviews, but additionally to the optimum remedy of myeloma sufferers today.
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72. show that dioxin exposure was more likely to occur near water and was associated with an increased risk for MM. Examples used for this analysis included the increased incidence of myeloma in fisherman eating dioxin-contaminated fish on a regular basis in several locations around the world, including Alaska, the Baltic Sea, waters around the United Kingdom, and Lake Okeechobee, Florida. Further support comes from studies of individuals exposed to high levels of dioxins secondary to the industrial explosion in Seveso, Italy, as well as the increased incidence in myeloma in obese patients (owing to the accumulation of dioxins in fatty tissue).
75. Lewis D, Garrison A, Wommack K, Whittemore A, Steudler P, Melillo J. Influence of environmental changes on degradation of chiral pollutants in soils. Nature 1999; 401:898-901. 76. Davis D, Magee B. Cancer and industrial chemical production. Science 1979; 206: 1356-1357. 77. Methods for investigating localized clustering of disease. In: Alexander FE, Boyle P, eds. IARC Scientific Publications No. 135. Lyon, France: Oxford University Press; 1996. 78. Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans.
In this proposed model, these precursor cells could then sustain the plasma cell pool through differentiation in a manner akin to the process that occurs in chronic myelogenous leukemia. Recent advances in molecular biological techniques From: Current Clinical Oncology: Biology and Management of Multiple Myeloma Edited by: J. R. , Totowa, NJ 37 38 Vescio and Berenson have allowed investigators to address this question using immunoglobulin gene analysis. Immunoglobulin gene rearrangement occurs at set time points during B-cell maturation.
Biology and Management of Multiple Myeloma by James S. Malpas MD DPhil FRCP FRCR FRCPCH, Daniel E. Bergsagel CM MD DPhil, Robert A. Kyle MD, Kenneth C. Anderson MD