By Anthony H. Futerman
The quantity assembles present info at the position of ceramide as a signalling molecule in sixteen chapters written by means of best staff during this sector. particular awareness is given to mechanisms of study of ceramide and its biophysical houses, on enzymes of ceramide metabolism and down-stream goals of ceramide, at the cross-talk of ceramide signalling with different signalling pathways, and at the position of ceramide in neuronal signalling. eventually, the publication closes with a bit at the healing implications of ceramide motion, within the components of cannabinoid motion, chemotherapy, and atherosclerosis, and illustrates the aptitude clinical value of delineating the jobs of ceramide in phone signalling. this is often the 1st quantity in particular dedicated to ceramide signalling, and should act as a useful source for simple and scientific researchers and graduate scholars wishing to get a cutting-edge evaluation of this quickly relocating box.
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Additional info for Ceramide Signaling (Molecular Biology Intelligence Unit)
Therefore, it might be possible that at least some of those infective organisms trigger the formation of ceramideenriched membrane rafts to infect mammalian target cells. Ceramide-Mediated Receptor Clustering 25 In summary, ceramide has been demonstrated to have a central role in the cellular response to a variety of stimuli. Ceramide functions as a messenger to directly regulate the activity of several cellular proteins. Second, it modifies sphingolipid enriched membrane rafts to form signaling platforms.
Com and Kluwer Academic / Plenum Publishers. 30 Ceramide Signaling Figure 1. Hydrolysis of ceramides by alkaline ceramidases. aCER, alkaline ceramidase; aDHC, alkaline dihydroceramidase; aPHC, alkaline phytoceramidase; SPHK, sphingosine kinase. sphingoid base moieties: ceramide contains sphingosine which has a double bond at the C4-5 position in the sphingoid base backbone; dihydroceramide contains dihydropshingosine which does not have a double bond; and phytoceramide contains phytosphingosine which has an additional hydroxyl group, but no double bond.
Tsugane K, Tamiya-Koizumi K, Nagino M et al. A possible role of nuclear ceramide and sphingosine in hepatocyte apoptosis in rat liver. J Hepatol 1999; 31:8-17. 27. Elleder M. Niemann-Pick disease. Pathol Res Pract 1989; 185:293-328. 28. Wiegmann K, Schutze S, Machleidt T et al. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 1994; 78:1005-1015. 29. Bezombes C, Segui B, Cuvillier O et al. Lysosomal sphingomyelinase is not solicited for apoptosis signaling.
Ceramide Signaling (Molecular Biology Intelligence Unit) by Anthony H. Futerman