New PDF release: Circulating tumor cells : isolation and analysis

By Z. Hugh Fan

ISBN-10: 1118915534

ISBN-13: 9781118915530

ISBN-10: 1119244536

ISBN-13: 9781119244530

ISBN-10: 1119244544

ISBN-13: 9781119244547

ISBN-10: 1119244552

ISBN-13: 9781119244554

Introduces the reader to Circulating Tumor Cells (CTCs), their isolation technique and research, and commercially to be had structures -Presents the historic standpoint and the evaluate of the sphere of circulating tumor cells (CTCs) -Discusses the state-of-art tools for CTC isolation, starting from the macro- to micro-scale, from confident focus to detrimental depletion, and from biological-property-enabled to Read more...

summary: Introduces the reader to Circulating Tumor Cells (CTCs), their isolation procedure and research, and commercially on hand structures -Presents the ancient viewpoint and the review of the sphere of circulating tumor cells (CTCs) -Discusses the state-of-art equipment for CTC isolation, starting from the macro- to micro-scale, from confident focus to adverse depletion, and from biological-property-enabled to physical-property-based methods -Details commercially on hand CTC systems -Describes post-isolation research and medical translation -Provides a word list of clinical phrases on the topic of CTCs

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The new design used microvortices to maximize the number of interactions between CTCs and the antibody-coated chip surface. CTCs were detected in 14 of 15 (93%) patients with metastatic disease. Captured CTCs could be visualized using both immunofluorescenc conjugated antibodies or standard immunocytochemical stains. More recently, this group has developed another microfluidi cell sorting device, the CTC-iChip, which uses size-based lateral displacement, inertial focusing, and magnetophoresis to achieve both antigen-dependent and antigen-independent CTC capture from whole blood.

17. M. (1965) Cancer cells in the peripheral blood: a second look. Acta Cytologica, 9, 169–174. 18. T. , and Anderson, D. (1962) Prognostic import of circulating cancer cells after curative surgery: a long time follow up study. Annals of Surgery, 155, 733–740. 19. C. (1955) Cancer cells in the circulating blood; a clinical study on the occurrence of cancer cells in the peripheral blood and in venous blood draining the tumour area at operation. Acta Chirurgica Scandinavica. Supplementum, 201, 1–70.

There was a linear relationship between the density of perfused vessels and the concentration of detectable tumor cells in the effluent Metastases, which were first detectable on Day 10, increased with time and were directly related to the concentration of tumor cell clumps (four or more cells) in the effluent The aforementioned studies suggested that tumor vascularization and the resultant entry of tumor cell clumps into the circulation were critical events in the initiation of metastases. These results propagated new types of experiments to look for CTCs [28].

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Circulating tumor cells : isolation and analysis by Z. Hugh Fan


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