By Peter G Isaacson; A J Norton
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G. rheumatoid arthritis and Wegener’s granulomatosis,38,39 have been linked to an increased 03-Cavelli-8045:03-Cavelli-8045 20 4/28/2008 4:06 PM Page 20 EXTRANODAL LYMPHOMAS risk of NHL in general, and PE-NHL in particular. 3). It has been suggested that therapy with immunosuppressive medications such as steroids and azathioprine could cause this increase. 42 Studies of patients with autoimmune inflammatory bowel disease have reported variable findings. 47 Morphologically, HCV-associated lymphomas represent a variety of histological subtypes, including marginal zone (splenic, nodal, and extranodal), small lymphocytic, lymphoplasmacytic, and DLBCL.
35 The majority of HIV-associated NHLs are of aggressive B-cell histology and very often present with extranodal involvement (see Chapter 25). Sites rarely involved in HIV-negative individuals are described. For example, involvement of the anorectal region has been reported in homosexual men with AIDS, suggesting the importance of local etiological factors. Also, the occurrence of primary effusion lymphoma (PEL) is associated with an immunodeficient state and the presence of human herpes virus 8 (HHV-8).
Clinicopathological features of extranodal lymphomas: Kuwait experience. Oncology 2004; 67: 382–9. 12. Shome DK, George SM, Al-Hilli F, Satir AA. Spectrum of malignant lymphomas in Bahrain. Leitmotif of a regional pattern. Saudi Med J 2004; 25: 164–7. 13. Doglioni C, Wotherspoon AC, Moschini A, de Boni M, Isaacson PG. High incidence of primary gastric lymphoma in northeastern Italy. Lancet 1992; 339(8797): 834–5. 14. Howell WM, Leung ST, Jones DB, et al. HLA-DRB, -DQA and -DQB polymorphism in celiac disease and enteropathy-associated T-cell lymphoma.
Extranodal lymphomas by Peter G Isaacson; A J Norton