Fungal Infections in the Immunocompromised Patient - download pdf or read online

By John R. Wingard, Elias Anaissie

ISBN-10: 082475428X

ISBN-13: 9780824754280

ISBN-10: 0849354641

ISBN-13: 9780849354649

In contrast to the other resource at the topic, this reference presents an up to date account of fungal syndromes in immunocompromised sufferers and gives professional descriptions in their scientific manifestations and settings during which they reason illness-covering the professionals and cons of present and rising diagnostic measures, innovations to include new diagnostic instruments and coverings into proven medical practices, and the latest healing options in sufferer care.

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Additional resources for Fungal Infections in the Immunocompromised Patient (Infectious Disease and Therapy)

Example text

Depletion of CD4 and CD8 in mice worsens experimental infections (CD4 depletion alone is worse than CD8 depletion) (205) Histoplasma capsulatum: Type 1 cells and cytokines (Table 3) critical for protection in animal models (113). Paracoccidioides brasiliensis: Type 1 Histoplasma capsulatum: Phagocytosis of yeast form, migration to lymph nodes, antigen presentation to T-cells, production of IL-12, and induction of a type 1 response. Coccidioides immitis: DC pulsed by a Coccicioides lysate mature and induce a specific TH1 response in vitro (191).

The presence of the CD4þ and CD8þ molecules on the surface of T-cells is indispensable for the lymphocyte to respond, initiate the first-signal transduction event leading to cell maturation and promotion of adhesion of the TCR to the MHC–peptide complex. Once the peptide is recognized, CD3 and z can lead to functional activation of the T-cell. CD2 binds to LFA-3 and is important for both adhesion and activation. The second signal is provided by the costimulatory APC molecules B7-1 (CD80) and B7-2 (CD86).

1. Antigen Recognition To present the antigen to T-cells, the APCs, mainly immature DCs, have to uptake and process the antigen. Immature DCs are located in the skin and mucosa (gastrointestinal, respiratory tract, genitourinary tract) where they capture microbial protein antigens, process them, and transport them to the draining lymph nodes where they present them to T-cells. During this process, DCs become mature (Fig. 1–IV). The process is different according to the source of the antigen, which can be extra- or intracellular (Fig.

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Fungal Infections in the Immunocompromised Patient (Infectious Disease and Therapy) by John R. Wingard, Elias Anaissie


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