By Timothy P Hughes, David M Ross, Junia V Melo
This concise, clinically targeted pocket guide assembles and synthesizes the most recent advancements and traits within the analysis and therapy of CML and offers an authoritative and handy precis of the newest development in TKI trials, the molecular tracking of CML responses, and the improvement of latest cures to beat resistance and increase sufferer care. continual myeloid leukemia (CML) is an extraordinary kind of leukemia (1–2 in line with 100,000 humans) yet is the most typical power myeloproliferative neoplasm. CML continues to be a key version for the enhanced knowing of the pathophysiology of a malignancy at a molecular point; CML used to be the 1st melanoma to be linked to a habitual chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its linked fusion gene BCR-ABL1. The medical end result for sufferers with CML has replaced dramatically some time past 15 years and this has been as a result improvement of tyrosine kinase inhibitors (TKIs), compounds that inhibit the job of the oncogenic BCR-ABL1 protein. a couple of first-, moment- and third-generation TKIs at the moment are on hand for the remedy of CML, even though a couple of remedy demanding situations stay, no longer least the advance of treatment-resistant CML. Parallel to the improvement of particular medications for treating CML, significant advances were made within the box of disorder tracking and standardization of reaction standards.
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Extra info for Handbook of Chronic Myeloid Leukemia
Branford S, Hughes TP. Diagnosis and monitoring of chronic myeloid leukemia by qualitative and quantitative RT-PCR. In: Iland HJ, Hertzberg M, Marlton P, eds. Myeloid Leukemia: Methods and Protocols, Methods in Molecular Medicine. Totawa, NJ: Humana Press; 2006:69-92. Cross NC, Melo JV, Feng L, Goldman JM. An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders. Leukemia. 1994;8:186-189. de la Fuente J, Merx K, Steer EJ, et al. ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia.
Leukemia. 2003;17:2474-2486. Gabert J, Beillard E, van der Velden VHJ, et al. Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program. Leukemia. 2003;17:2318-2357. Branford S, Cross NC, Hochhaus A, et al. Rationale for the recommendations for harmonizing current methodology for detecting BCR-ABL transcripts in patients with chronic myeloid leukaemia.
Beillard E, Pallisgaard N, van der Velden VHJ, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using ‘real-time’ quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program. Leukemia. 2003;17:2474-2486. Gabert J, Beillard E, van der Velden VHJ, et al. Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.
Handbook of Chronic Myeloid Leukemia by Timothy P Hughes, David M Ross, Junia V Melo