By Satinder Ahuja, Stephen Scypinski
Handbook of contemporary Pharmaceutical Analysis, Second Edition, synthesizes the advanced study and up to date adjustments within the field, while protecting the techniques and technology required for present day laboratories. The work integrates technique, case experiences, methodologies, and implications of latest regulatory buildings, delivering whole assurance of caliber insurance from the purpose of discovery to the purpose of use.
- Treats pharmaceutical research (PA) as an crucial accomplice to the drug improvement method instead of as a carrier to it
- Covers technique improvement, validation, choice, checking out, modeling, and simulation reviews mixed with complex exploration of assays, impurity checking out, biomolecules, and chiral separations
- Features detailed coverage of QA, ethics, and regulatory assistance (quality by means of layout, strong production practice), in addition to high-tech methodologies and applied sciences from ''lab-on-a-chip'' to LC-MS, LC-NMR, and LC-NMR-MS
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Additional info for Handbook of Modern Pharmaceutical Analysis
These derived descriptors for particle size all begin with a homogenization of the length and width descriptors into either a circular or spherical equivalent, and make use of the ordinary geometrical equations associated with the derived equivalent. For instance, the perimeter diameter is defined as the diameter of a circle having the same perimeter as the projected outline of the particle. The surface diameter is taken as the diameter of a sphere having the same surface area as the particle, and the volume diameter is defined as the diameter of a sphere having the same volume as the particle.
191 This density parameter is normally measured by helium pycnometry, where the volume occupied by a known mass of powder is determined by measuring the volume of gas displaced by the powder. The true density of a solid is an intrinsic property characteristic of the analyte, and is determined by the composition of the unit cell. Inverse gas chromatography (IGC) is a relative new method that has been used to evaluate the surface energy of powdered materials. 198,199 C. Mechanical Properties of Powders Evaluation of the mechanical characteristics of powdered solids is vitally important to the processing of these materials.
It was also found that compacts prepared from the coarser size fractions contained significantly lower surface areas than compacts prepared from the fine fractions. 188 This method is widely used to determine the pore size distribution of porous materials, and the void size of tablets and compacts. The method is based on the capillary rise phenomenon in which excess pressure is required to force a nonwetting liquid into a narrow volume. Mercury, with its contact angle on glass of approximately 140 , is most commonly used as the intrusion fluid.
Handbook of Modern Pharmaceutical Analysis by Satinder Ahuja, Stephen Scypinski