Read e-book online Hematology and Coagulation: A Comprehensive Review for Board PDF

By Amer Wahed, Amitava Dasgupta

ISBN-10: 0128002417

ISBN-13: 9780128002414

Hematology and Coagulation is a transparent and easy-to-read presentation of middle themes and precise case reports that illustrate the applying of hematopathology wisdom to daily sufferer care. with the intention to prevail, in addition to to cross the yankee Board of Pathology exam, all pathology citizens should have a superb command of hematopathology, together with the demanding subject matters of hematology and coagulation. Hematology and Coagulation meets this problem head on.

This simple primer bargains functional examples of ways issues functionality within the hematopathology medical institution in addition to precious lists, pattern questions, and a bullet-point structure excellent for fast pre-board evaluate. This publication presents in simple terms the main clinically appropriate examples designed to coach senior scientific scholars, citizens and fellows and "refresh" the data base, with out overwhelming scholars, citizens, and clinicians.

  • Takes a pragmatic and easy-to-read method of knowing hematology and coagulation at a suitable point for either board coaching in addition to a certified refresher course
  • Covers all very important medical info present in better textbooks in a extra succinct and easy-to-understand manner
  • Covers crucial strategies in hematopathology in one of these manner that fellows and clinicians comprehend the tools with no need to develop into experts within the field

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Extra info for Hematology and Coagulation: A Comprehensive Review for Board Preparation, Certification and Clinical Practice

Example text

Hemolysis is classically extravascular. The IgG-coated red cells are destroyed by splenic macrophages. Splenomegaly is thus a feature. In CHAD, IgM antibodies are formed against red cell antigens. Agglutination of red cells can occur at low temperatures, and complement activation may result in intravascular hemolysis. Antibodies are often directed against I antigens. There are several subtypes of this condition: ■ ■ ■ Acute postinfectious: Acute, self-limited, younger patients Chronic idiopathic: Insidious, older patients Cold agglutinin disease (CAD): Insidious, elderly women, associated with lymphoproliferative malignancy.

4 Hemolytic Anemia prevalence of this disorder is in Sub-Saharan Africa, followed by North Africa and the Middle East. Interestingly, this disorder protects individuals from infection by the malaria parasite. Normally, two isotypes of G6PD—A and B—can be differentiated based on electrophoretic mobility, and the B isoform is the most common type of enzyme found in all population groups. However, the A isoform, found in 20% of black men in the United States, migrates more rapidly on electrophoretic gels than does the B isoform and has similar enzyme activity to the B isoform.

In the three normoblasts, the cytoplasm will change color from blue (basophilic normoblast) to gray to gray-orange (late normoblast). Megakaryocytes mature through endomitosis. Here, the nuclear DNA content increases in multiples of two. There is no nuclear or cytoplasmic division. Thus, in the bone marrow there exists megakaryocytes, which are 2 N, 4 N, 8 N, 16 N, and 32 N. The dominant ploidy category is 16 N. Megakaryocytes do not cluster. , myelodysplasia). In aplastic anemia, trephine biopsy is crucial to document bone marrow hypocellularity.

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Hematology and Coagulation: A Comprehensive Review for Board Preparation, Certification and Clinical Practice by Amer Wahed, Amitava Dasgupta

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