Hemolytic Anemia in Disorders of Red Cell Metabolism - download pdf or read online

By Ernest Beutler M.D. (auth.)

ISBN-10: 1468424572

ISBN-13: 9781468424577

ISBN-10: 1468424599

ISBN-13: 9781468424591

I am ready to foretell that this monograph through Dr. Ernest Beutler will lengthy function a version for monographs facing themes in scientific technological know-how. I make this daring assertion simply because we come upon during this paintings a level of accuracy and authoritativeness well past that present in a lot of the scientific literature. Too usually, a monograph is just a evaluate of previous stories. The guidance of an exhaustive and entirely exact research reminiscent of the current one is a truly hard job; as a result, many authors make vast use of the experiences of previous writers assum­ ing that the latter have checked and evaluated each one formerly released record. regrettably, although, this assumption of validity has now not al­ methods been right. Dr. Beutler, who's an international authority at the topic approximately which he writes, was resolute to make this e-book as right and entire as attainable, and, to this finish, has checked all of the unique assets. Nowhere else will such an exhaustive bibliography be came upon. additionally, he has additionally undertaken to reevaluate within the mild of present wisdom fabric pub­ lished in previous days. This he's eminently capable of do, and in a few in­ stances his investigations have led to new interpretations. the result's a quantity that would be well-known as actually the final word in this very important subject.

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Extra info for Hemolytic Anemia in Disorders of Red Cell Metabolism

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QUANTITATIVE BESTIMMUNG VDN SEDDHEPTULOSE-7-PHDSPHAT UNO EINIGE EIGENSCHAFTEN DER TRANSKETDLASE DER ERYTHROCYTEN UNO DES BLUTSERUMS. BIDCHEM Z 330:497-508 51. S. , 1961, THE PENTOSE PHDSPHATE METABOLIC PATHWAY IN THE HUMAN ERYTHROCYTE. II. THE TRANSKETOLASE AND TRANSALDOLASE ACTIVITY OF THE HUMAN ERYTHRDCYTE. CAN J BIOCHEM 39:533-545 52. , 1968, GLUCOSE AND MANNOSE DIPHDSPHATES IN THE RED BLOOD CELL. BIOCHIM BIOPHYS ACTA 156:231-239 53. L. , 1976, PURIFICATION OF NORMAL AND INACTIVE GALACTOSEMIC GALACTOSE-I-PHDSPHATE URIDYLTRANSFERASE FROM HUMAN RED CELLS.

After treating their subjects' blood with sodium nitrite and reducing methemoglobin in the presence of Nile blue sulfate, these investigators identified G-6-PD-deficient cells histochemically using the methemoglobin elution technique. They observed many more parasites in G-6-PD-normal than in G-6-PD-deficient erythrocytes (Fig. 5). This suggested that either the G-6-PD-deficient environment was an inhospitable one for the malaria parasite or, alternatively, that deficient cells that had been parasitized by malaria were rapidly sequestered by the spleen, depriving the malaria parasite of the opportunity to multiply and to infect other erythrocytes.

Z o ;:: ..... 30MG BASE / DAY FIGURE 3. The effect of the administra tion of 30 mg of primaquine daily on " Cr-Iabeled red cells from a primaquine-sensitive (G-6-PD-deficient) donor transfused into normal recipients. The administration of primaquine resulted in accelerated destruction of the transfused cells. ) 26 CHAPTER 2 • • • • • FIGURE 4. In vitro Heinz body formation in normal (left) and primaquine-sensitive' (G6-PD-deficient) (right) red cells. 6. The suspension was mixed and aerated immediately and after 2 hr.

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Hemolytic Anemia in Disorders of Red Cell Metabolism by Ernest Beutler M.D. (auth.)


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