By Giuseppe Lippi
Outlined as purple blood mobile holiday down and the discharge of hemoglobin and intracellular contents into the plasma, haemolysis can heavily influence sufferer care in addition to the laboratory's popularity via its have an effect on on attempt effects. for that reason, the ecu Preanalytical medical Committee, in collaboration with the overseas Federation of scientific Chemistry operating staff on sufferer security, have designed a questionnaire to assemble info on incidence and administration of haemolytic specimens pointed out the scientific laboratories for scientific chemistry trying out. the hot e-book can help determine the components the place haemolysis happens most often, that can, in flip, consultant additional research approximately why it truly is happening. as soon as those parts are recognized, practices and strategies should be carried out to dramatically lessen haemolysis and keep away from inaccurate laboratory effects affecting sufferer care and lengthening laboratory expenses.
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Extra info for In Vitro and In Vivo Hemolysis: An unresolved dispute in laboratory medicine
7% hemolysis in samples obtained through the IV catheter vs. 8% in those obtained with separate vacuum tube venipuncture), and Grant (20% hemolysis and test cancellation in blood drawn through IV catheters vs. <1% in blood samples collected by straight needle) . , <22-gauge), blood drawing categorized as difﬁcult, number of tries for IV placement, small blood tube size, and discharge diagnoses of respiratory, gastrointestinal, reproductive, dermatologic, and endocrine diseases . A critical review was carried out to pool results of observational, descriptive, comparative, and experimental studies comparing hemolysis between specimens collected from IV catheters and those collected from venipunctures in the ED.
In the face of all this evidence, it is suggested that blood samples not be collected when new IV catheters are started or from established IV catheters. Some notable exceptions might include instances where patients are receiving thrombolytic agents or are at increased risk of bleeding, or possibly in an emergency situation where there is limited vascular access, even though hemolysis may still result and delay critical treatment. 3 Blood collection from butterﬂy devices The butterﬂy device is a small needle attached to ﬂexible plastic wings that is connected to ﬂexible extension tubing (uFig.
Therefore the reported studies and manufacturers’ information led the authors to conclude, with class III evidence (not acceptable or useful; may be harmful), that the collection of laboratory specimens from peripheral IV catheters was not to be recommended. In agreement with these considerations, a study of Burns and Yoshikawa  identiﬁed the widespread practice of collecting blood from plastic catheters connected to patients (aimed to reduce the number of venipunctures) as the leading problem causing hemolysis in the ED.
In Vitro and In Vivo Hemolysis: An unresolved dispute in laboratory medicine by Giuseppe Lippi