Download e-book for kindle: Lecture notes. / Haematology by Chris Hatton, (Hematologist); et al

By Chris Hatton, (Hematologist); et al

ISBN-10: 0470673591

ISBN-13: 9780470673591

ISBN-10: 1118496841

ISBN-13: 9781118496848

Haematology Lecture Notes is an available and concise best-selling examine advisor, outlining the body structure, pathology and therapy of the most typical blood issues. generally revised and up to date to mirror the significant advances within the realizing of the molecular biology and pathogenesis of haematological issues, it offers the middle wisdom required by means of all scientific scholars and junior doctors.

Key good points include:

  • New fabric on coagulation and transfusion
  • Expanded assurance of haematopoiesis
  • A whole replace of all malignant haematology content

A fresh better half site at www.lecturenoteseries.com/haematology that includes interactive MCQs with suggestions on each one solution chosen, bankruptcy summaries and revision notes in PowerPoint and PDF codecs, and all of the figures from the publication in PowerPoint format

Whether drawing close haematology for the 1st time, or trying to find a refresher, Haematology Lecture Notes will permit scholars and junior medical professionals to strengthen an figuring out of either the fundamental technological know-how and scientific facets of this specialty.

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Extra resources for Lecture notes. / Haematology

Sample text

Since G6PD has a critical role in maintaining the pool of reducing power in the erythrocyte, patients with low levels of the enzyme are poorly protected against oxidative challenge – with some medications and even foods resulting in marked oxidative damage to the red cell. When the red cell is exposed to oxidants, haemoglobin is converted to methaemoglobin and denatured. 7). 8). Red cells with oxidative membrane damage will be removed extravascularly by the spleen, though acute responses to a severe oxidative challenge may also provoke intravascular haemolysis.

The test can also be made specific for individual subtypes of IgG and for complement components that may be found on the red cell surface in AIHA. It should be noted, however, that a positive direct antiglobulin test does not always imply active haemolysis: studies of healthy blood donors suggest that up to 1 in 10,000 of the population will have a positive test without haematological consequences. In most patients, the haemolysis can be limited by treatment with prednisolone, which is initially given in high doses.

Hay and D. Keeling. © 2013 John Wiley & Sons, Ltd. Published 2013 by John Wiley & Sons, Ltd. 1 Oxygen dissociation curves of human blood. 1). The globin chain composition of haemoglobin can also influence its oxygen affinity. Although all normal haemoglobins consist of two pairs of distinct globin polypeptides, the precise nature of these globin chains changes during intrauterine and postnatal life. The α chains are encoded on chromosome 16 and are arranged in the order in which they are expressed during development: the embryonic ζ globin chain first, followed by the adult α globin chain.

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Lecture notes. / Haematology by Chris Hatton, (Hematologist); et al


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