By Wilfried M.A. Niessen
"...Discusses how the approach works and the way to interpret effects. ...Describes the influence of [LC-MS] on small-molecule and biomolecular applications...- Biophotonics foreign, August 2006Featuring new chapters and wide revisions in the course of the e-book, this e-book explains the best way to use LC-MS and interpret facts for numerous disciplines. putting a higher emphasis on functions than earlier variants, this version additionally dedicates greater than two-thirds of the textual content to interpreting new advancements of LC-MS in rising software parts, together with environmental, food-safety, and medical research in addition to proteomics, pharmaceutical drug discovery and traditional items learn. each one bankruptcy examines how contemporary advances techniques, and applied sciences formed every one of those disciplines, supported via such a lot correct literature to be had.
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Extra info for Liquid chromatography--mass spectrometry
By filtering low-mass interferences in the RF-only ion guide prior to injection into the trap , or by the application of auxiliary RF waveforms to the end caps . C At this stage, different MS experiments can be performed. In the full-scan mode, ions of different m/z are consecutively ejected from the trap towards the external detector by ramping the RF voltage at the ring electrode. Resonant ion ejection may be supported by additional waveforms applied to the end-cap electrodes. Ion ejection can be achieved with unit-mass resolution, or at enhanced resolution by slowing down the scan rate .
23 Analyte ionization . . . . . . . . . . . . . . . . . 23 Information from mass spectrometry . . . . . . . . . . 27 Mass analysis . . . . . . . . . . . . . . . . . . . 32 References . . . . . . . . . . . . . . . . . . . . 45 1. Introduction Mass spectrometry (MS) is based on the production of ions, that are subsequently separated or filtered according to their mass-to-charge (m/z) ratio and detected. The resulting mass spectrum is a plot of the (relative) abundance of the generated ions as a function of the m/z.
Rudolph, M. Raedts, (I)AC: a versatile tool for fast and selective purification, concentration, isolation and analysis, J. Pharm. Biomed. , 24 (2001) 825. 15. -C. Hennion, V. Pichon, Immuno-based sample preparation for trace analysis, J. Chromatogr. A, 1000 (2003) 29. 16. Y. Hsieh, G. Wang, Y. Wang, S. -M. Brisson, K. A. Korfmacher, Simultaneous determination of a drug candidate and its metabolite in rat plasma samples using ultrafast monolithic column LC–MS–MS, Rapid Commun. , 16 (2002) 944. 17.
Liquid chromatography--mass spectrometry by Wilfried M.A. Niessen