By Charles L. Schmidt
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Additional info for Mantle Cell Lymphoma: Clinical Characteristics, Prevalence and Treatment Options
H. & Orazi, A. Chronic lymphocytic leukemia/small lymphocytic lymphoma with trisomy 12 and focal cyclin d1 expression: a potential diagnostic pitfall. CO;2 (2005).  Gradowski, J. F. et al. Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression. 1309/ AJCPIVKZRMPF93ET (2012). de Boer, C. J. et al. Involvement of the CCND1 gene in hairy cell leukemia. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 7, 251-256 (1996).
1months) although there was no statistically significant difference in OS.  The combination of bendamustine and rituximab with cytarabine was evaluated in a Phase II study of patients older than 65 who were not eligible for aggressive chemotherapy.  Both previously untreated and patient who had received rituximab based regimen were included in the study, among untreated patients the ORR was 100% and the 2 year PFS was 95%. Among treated patients ORR was 70% with PFS of 70% at 2 years. A phase III double-blind study of ibrutinib in combination with BR versus BR for the treatment of patients with newly diagnosed MCL is currently ongoing (NCT01776840).
Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. 140 (2010). Mozos, A. et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. 010264 (2009). Dictor, M. et al. Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma. 008474 (2009). , Haferlach, T. & Schnittger, S.
Mantle Cell Lymphoma: Clinical Characteristics, Prevalence and Treatment Options by Charles L. Schmidt