By Philip Lanzkowsky, Jeffrey M. Lipton, Jonathan D. Fish
Lanzkowsky’s handbook of Pediatric Hematology and Oncology, 6th Edition,
is a finished publication on sufferer administration, replete with algorithms and circulate diagrams on analysis and administration. Reflecting the enormous advances within the remedy and administration of hematologic and oncologic ailments in little ones, the 6th variation of this profitable scientific handbook has been totally up-to-date to include all present therapy protocols, new medicinal drugs, and administration methods. Its concise and easy-to-read structure will let readers to make exact diagnoses and allow them to regard sufferers with no need to reference higher clinical textbooks.
Based at the new criteria of genetic class and prognostic info that experience arisen some time past 5 years, the 6th variation comprises new chapters (Diagnostic, Molecular, and Genomic Methodologies for the Hematologist, Transfusion medication) and a number of other new accelerated chapters that have been formerly sections in consolidated chapters (Myelodysplasia, Myeloid Leukemias, Lymphoid Leukemias, Hemolytic Anemia, and problems of Coagulation).
- Presents a concise, systematic method of all pediatric hematologic and oncologic issues in a single manual
- Offers an alternative choice to larger references which in simple terms conceal both oncologic or hematologic issues in two times as many pages
- Presents an easy-to-read layout: a number of tables, charts, and flow-diagrams for prognosis and administration of pediatric hematologic and oncologic disorders
- Includes 2 new chapters and a number of other improved chapters: Diagnostic, Molecular and Genomic Methodologies for the Hematologist, Transfusion medication, Myelodysplasia, Myeloid Leukemias, and Lymphoid Leukemias
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Additional resources for Manual of pediatric hematology and oncology
Table 2-4 lists the clinical and laboratory features of isoimmune hemolysis due to Rh and ABO incompatibility. Diagnosis 1. Hemoglobin decreased 2. Smear: spherocytosis in 80% of infants, reticulocytosis, marked polychromasia Anemia During the Neonatal Period 25 Table 2-4. Clinical and Laboratory Features of Isoimmune Hemolysis Caused by Rh and ABO Incompatibility Feature Rh disease ABO incompatibility Clinical evaluation Frequency Occurrence in firstborn Predictably severe in subsequent pregnancies Stillbirth and/or hydrops Pallor Jaundice Hepatosplenomegaly Incidence of late anemia Unusual 5% Usually Common 40–50% No Occasional Marked Marked Marked Common Rare Minimal Minimal (occasionally marked) Minimal Uncommon Laboratory findings Blood type, mother Blood type, infant Antibody type Coombs’ test, direct Coombs’ test, indirect Hemoglobin level Serum bilirubin Red cell morphology Rh negative Rh positive Incomplete (7S) Positive Positive Very low Markedly elevated Nucleated RBCs O A or B or AB Immune (7S) Usually positive Usually positive Moderately low Variably elevated Spherocytes Yes No ~2:3 Rh-negative group specific, when possible ~1:10 Rh same as infant group O only Treatment Need for antenatal management Exchange transfusion Frequency Donor blood type 3.
Iron deficiency and related nutritional anemias. In: Nathan DG, Oski FA, editors. Hematology of Infancy and Childhood. Philadelphia: WB Saunders, 1987. Dallman, PR. Progress in the prevention of iron deficiency in infants. Acta Paediatr Scan (Suppl) 1990;365:28–37. Dallman PR, Reeves JD. Laboratory diagnosis of iron deficiency. In: Steckel A, editor. Iron Nutrition in Infancy and Childhood. New York: Raven Press, 1984;11. Lanzkowsky P. Iron deficiency anemias: A systemic disease. Trans College Medicine South Africa, July–December, 1982;67–113.
Serum ferritin: decreased 4. Serum iron and iron binding capacity a. Decreased serum iron b. Increased iron-binding capacity c. Decreased iron saturation (16% or less) 5. Therapeutic responses to oral iron a. Reticulocytosis with peak 5–10 days after institution of therapy b. 4 g/dL/day or hematocrit rises 1%/day 6. Serum transferrin receptor levela 7. Red blood cell zinc protoporphyrin/heme ratioa 8. Bone marrowb a. Delayed cytoplasmic maturation b. Decreased or absent stainable iron a Rarely required or readily available.
Manual of pediatric hematology and oncology by Philip Lanzkowsky, Jeffrey M. Lipton, Jonathan D. Fish