By Laurent Bernard Fay, Martin Kussmann, Peter S Belton, Gerry Downey, Arnis Kuksis, Gregory Dolnikowski, Jean - Luc Wolfender, Dwight Matthews, Matej Oresic, Bruce German, Claudio Corradini, Nicole Packer, Michael Affolter
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The amplitude of the oscillation determines the m/z range of ions that will be trapped. Ion stability depends on the mass and charge of the ion, the size of the ion trap (r), the oscillating frequency of the radio frequency (w), and the amplitude of the voltage on the ring electrode (V). The dependence of ion motion on these parameters is described by the parameter qz: qz¼ 4eV=mr2 w2 Linear ramping of the radio frequency voltage will create unstable ion trajectories. Ions with lower m/z values will be ejected before ions with higher m/z values.
Can be described by the number of ions collected per input of molecule; the absolute sensitivity is around one ion per 800–1200 molecules in dual inlet mode. These ions are accelerated through a ﬂight tube in an electromagnetic ﬁeld. Finally they are separated according to their m/z ratio and counted by a multiple Faraday cup collector to eliminate ﬂuctuations in the ion beam intensity. For 13C measurements, the Faraday cups allow simultaneous measurement of three ions at m/z 44, 45, and 46. 24 The peak area of each isotopomer is measured and ﬁnally transformed into a 13 C/12C ratio using m/z 44, 45 and 46.
There are four possible scanning experiments: Product ion scan. A precursor ion is selected by the ﬁrst mass analyzer and then subjected to collision-activated dissociation in a collision cell. All resulting masses are detected in the second mass analyzer. Precursor ion scan. The product ion is selected in the second mass analyzer and the precursor masses are scanned in the ﬁrst mass analyzer. Neutral loss scan. The ﬁrst mass analyzer scans all masses. The second mass analyzer also scans, but at a deﬁned oﬀset from the ﬁrst mass analyzer.
Mass Spectrometry and Nutrition Research by Laurent Bernard Fay, Martin Kussmann, Peter S Belton, Gerry Downey, Arnis Kuksis, Gregory Dolnikowski, Jean - Luc Wolfender, Dwight Matthews, Matej Oresic, Bruce German, Claudio Corradini, Nicole Packer, Michael Affolter