By Peter J. Bayley, Larry R. Squire (auth.), Bruno Bontempi Ph.D., Alcino J. Silva, Yves Christen Ph.D. (eds.)
Memories: Molecules and Circuits
The questions of the way, the place and while reminiscence strains are shaped within the mind stay important matters in Cognitive Neuroscience. How do neuronal structures encode, consolidate and retrieve reminiscence? How are stories embedded into advanced neuronal networks? How do molecular mechanisms modulate the neuronal plasticity and functioning of those networks in the course of reminiscence processing? What are the elemental devices of computation within the mind? due to the advance of novel techniques, together with transgenic suggestions, sensible mind imaging, a number of mobilephone recording, practical genomics and proteomics, the decade has been witness to dramatic advances within the neurobiology, neuroanatomy, neurophysiology and neuropathology of studying and reminiscence methods.
This quantity surveys the hot advances and gives an integrative view of molecular, mobile, and structures point mechanisms underlying cognitive approaches in either animals and people. present state-of-the-art and destiny avenues are mentioned by way of distinct scientists who supply not just an outline of the underlying neurobiology of cognitive techniques from a uncomplicated technological know-how viewpoint, yet who additionally specialize in medical and healing elements surrounding impairments linked to issues that impact cognition.
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Additional info for Memories: Molecules and Circuits
In animals When it comes to studying temporally graded retrograde amnesia, animal models offer a certain number of advantages over human case studies (Squire 1992). First, the content and age of memories can be rigorously assessed across time points in a prospective manner, two parameters that are difﬁcult to control for in humans, where studies rely almost exclusively on retrospective questionnaires. Second, the location and extent of lesions are strictly circumscribed to the brain area of interest.
AA, anterograde amnesia been made and techniques such as PET, and more recently fMRI, have made it possible to visualize the human brain at work. Similar techniques are also available in small animals. One such technique is the (14 C)2-deoxyglucose autoradiographic method, which can be readily used in freely moving animals confronting various cognitive challenges (Sokoloff et al. 1977). Given that glucose is the sole energy source for neurons in normal physiological conditions, the measure of its rate of consumption in a given brain region enables to evaluate the level of functional implication of that region in a particular experimental situation.
Acknowledgements. Support was provided by grants from the CNRS (CNRS UMR 5106), the Action Concertée Incitative “Temps et Cerveau” and the Fédération pour la Recherche sur le Cerveau (FRC). We would like to thank our collaborators who contributed signiﬁcantly to the functional brain imaging experiments in mice described here, in particular Catherine LaurentDemir, Claude Destrade, Robert Jaffard, Thibault Maviel and Frédérique Menzaghi. References Amaral DG, Witter MP (1989) The three-dimensional organization of the hippocampal formation: a review of anatomical data.
Memories: Molecules and Circuits by Peter J. Bayley, Larry R. Squire (auth.), Bruno Bontempi Ph.D., Alcino J. Silva, Yves Christen Ph.D. (eds.)