By H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau, Charlotte Niemeyer
This e-book summarizes our present wisdom of MDS, from very easy facets to the medical administration. It presents tips to the analysis, an figuring out of ailment mechanisms, and a dialogue of remedy concepts.
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Extra resources for Myelodysplastic Syndromes (Hematologic Malignancies)
2 Nucleoporin Abnormality Nucleoporins are molecules involved in the nuclear import and export of proteins and RNAs (Radu et al. 1995). 5. Chimeric transcripts involving NUP98 combine the N-terminal GLFG repeats of NUP98 with the C-terminus of the partner gene (Ahuja et al. 1999; Arai et al. 1997; Nakamura et al. 1996; Nishiyama et al. 2 ´ Pathogenesis Egilmez et al. 1998; Slape and Aplan 2004). Up to 15 partnerships have been identified to date, clearly identifying NUP98 as a potentially important target in therapy-related leukemias and MDS.
Both intrinsic cellular defects and extrinsic factors are being investigated in ongoing research. Alterations in the immune-mediated signals, cytokine release, and other aspects of the bone marrow microenvironment have been implicated. Alterations in apoptosis appear to be a central feature of MDS. Increased apoptosis is frequently observed in the early stages of MDS. Further insight into the intrinsic and extrinsic factors that affect apoptosis is a central area of research and hold significant promise for the development of clinical therapies.
There is considerable overlap between mechanisms, and MDS is likely a heterogeneous group of diseases with a similar clinical phenotype. Other mutations have been described with RB, WT1, C/ EBPa and a variety of other genes with varying degrees of frequency. Their role in the pathogenesis of MDS is unclear. 10 Gene Expression Profiling cDNA microarray technology has revolutionized molecular biology and medicine. For details in MDS, see Chapter 5. Using commercially available chip technology, investigators have investigated the expression of several thousands of genes in a variety of cancers, including diffuse large B cell lymphoma, follicular lymphoma, acute myeloid leukemia and myelodysplastic syndromes (Lossos et al.
Myelodysplastic Syndromes (Hematologic Malignancies) by H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau, Charlotte Niemeyer