By Barbara J. Bain, Estella Matutes
Assembly the wishes for haematologists and medical chemists for an up to the moment reference, this atlas offers a visible presentation of myeloproliferative neoplasms and myeloid leukaemia. Compiled by means of major specialists within the united kingdom, each one person disorder is surveyed via bankruptcy, overlaying the scientific presentation, haematological and pathological positive factors, immunophenotyping and cytogenetic and genetic abnormalities. analysis and differential prognosis is mentioned, and diagnosis and healing procedures are reviewed. The e-book is seriously illustrated all through with color pictures and diagrams.This atlas fills a niche within the literature and is an important source for all haematologists. Its spouse quantity within the sequence includes an illustrated consultant to lymphoid malignancies. It presents the main up to date reference of its sort within the box of haematology. It assists visible research of symptoms and gives prepared to-use-information in an simply obtainable structure.
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Additional info for Myeloid Malignancies: An Atlas of Investigation and Diagnosis
The WHO has identified t(8;21), t(15;17) and inv(16). To these should probably be added t(1;22)(p13;q13). In the case of Ph-positive BCR-ABL1positive AML, the differential diagnosis is blast crisis of chronic myelogenous leukaemia. Very rarely, non-neoplastic conditions can be confused with AML. The bone marrow picture of ‘maturation arrest’ in patients with agranulocytosis has been confused with acute promyelocytic leukaemia. A similar picture can be seen in patients who have received granulocyte colony-stimulating factor (G-CSF) for neutropenia of various aetiologies.
17 Slovak ML, Bedell V, Popplewell L, Arber DA, Schoch C, Slater R et al. (2002). 21q22 balanced chromosome aberrations in therapy related haemopoietic disorders: report from an international workshop. Ge ne s, Chromosomes Cancer, 33, 379–344. qxd 56 5/12/10 10:48 AM Page 56 Acute myeloid leukaemia 18 Andersen MK, Larson RA, Muritzson N, Schnittger S, Jhanwar SC, Pedersen-Bjergaard J (2002). Balanced chromosome abnormalities inv(16) and t(15;17) in therapy related myelodysplastic syndromes and acute leukemia: report from an international workshop.
The immunophenotype can aid in the recognition of acute promyelocytic leukaemia, in which HLA-DR and CD34 are characteristically negative. In addition, some markers such as lysozyme, CD14 and CD64 may be useful indicators of monocytic differentiation. Immunofluorescence can be used to show the distribution of PML protein. In normal myeloid cells and in blast cells of most types of AML the distribution within the nucleus is in a small number of ‘nuclear bodies’, whereas in acute promyelocytic leukaemia there is a microparticulate distribution or diffuse cytoplasmic staining.
Myeloid Malignancies: An Atlas of Investigation and Diagnosis by Barbara J. Bain, Estella Matutes