By Giovanni Biggio, Robert H. Purdy, Ronald J. Bradley, R. Adron Harris PhD, Peter Jenner
International assessment of Neurobiology, quantity forty six offers in-depth reports on such ground-breaking issues as meeting and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disorder. This sequence deals the main complete and up to date info to be had and is a needs to for somebody within the box. incorporates a historic evaluation of neurosteroid learn encompasses a bankruptcy on neurosteroid biosynthesis and rules provides present equipment of neurosteroid size and research Discusses neurosteroid functionality in either the conventional and the pathological mind Chapters deal with the functionality of neurosteroid in: tension Receptor plasticity and serve as studying and reminiscence Alcohol use melancholy
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Additional resources for Neurosteroids and Brain Function
H. ), pp. 83 –91. Parthenon, New York. Gomez-Sanchez, C. , et al. (1996). Corticosteroid synthesis in the central nervous system. Endocr. Res. 22, 463 –470. Gower, D. , and Ruparelia, B. A. (1993). Olfaction in humans with special reference to odorous 16-androstenes: Their occurrence, perception and possible social, psychological and sexual impact. J. Endocrinol. 137, 167–187. , et al. (1994). Neurosteroidogenesis in rat retinas. J. Neurochem. 63, 86–96. , et al. (1995). A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/ 5- 4-isomerase (3β-HSD), is expressed in rat brain.
In general, they mediate their actions not through classic steroid hormone nuclear receptors but through ion-gated neurotransmitter receptors. This chapter summarizes the biochemistry of the enzymes involved in the biosynthesis of neurosteroids, their localization during development and in adulthood, and the regulation of their expression, highlighting both similarities and differences between expression in the brain and in classic steroidogenic tissues. 2001 Academic Press. C I. What Is a Neurosteroid?
1995). Symptoms related to the menopause and sex steroid treatments. In “NonReproductive Actions of Sex Steroids” (G. R. Bock and J. A. ), pp. 171–180. Wiley, Chichester. Baulieu, E. , et al. (1965). An adrenal-secreted “Androgen”: Dehydroisoandrosterone sulfate. Its metabolism and a tentative generalization on the metabolism of other steroid conjugates in man. Rec. Progr. Hormone Res. 21, 411–500. Baulieu, E. , et al. (1978). Steroid induced meiotic division in Xenopus laevis oocytes: Surface and calcium.
Neurosteroids and Brain Function by Giovanni Biggio, Robert H. Purdy, Ronald J. Bradley, R. Adron Harris PhD, Peter Jenner