New therapeutic agents in thrombosis and thrombolysis - download pdf or read online

By Jane E Freedman; Joseph Loscalzo

ISBN-10: 1420069233

ISBN-13: 9781420069235

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Extra info for New therapeutic agents in thrombosis and thrombolysis

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Since neither the coagulation factors nor platelet-based clotting systems act independently, more recent models of coagulation incorporate both systems in a cell-based model that more accurately depicts their interaction (6). 22 Giugliano Figure 2 First generation oral GP IIb/IIIa inhibitor phase III trials. Each of these five large studies demonstrated a higher rate of mortality with an oral GP IIb/IIIa inhibitor compared with aspirin monotherapy (8) Abbreviation: GP, glycoprotein. The hatched bar at the far right represents the one dose of lotrafiban studied in BRAVO.

Shebuski RJ, Kilgore KS. Role of inflammatory mediators in thrombogenesis. J Pharmacol Exp Ther 2002; 300:729–735. 32. Lindemann SW, Yost CC, Denis MM, et al. Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A 2004; 101:7076–7081. 33. Weyrich AS, Lindemann S, Zimmerman GA. The evolving role of platelets in inflammation. J Thromb Haemost 2003; 1:1897–1905. 34. Weyrich AS, Zimmerman GA. Platelets: signaling cells in the immune continuum.

Complexity of Patients While a good clinical trial evaluates a therapy in a well-defined cohort, the effect of the intervention may not be uniform across the population tested, and the risks or benefits cannot be easily generalized to other patients who differ from the population studied. Yet there is often considerable variability among patients with respect to clinical diagnosis, level of risk, and individual response to therapy, which makes sweeping generalizations treacherous. Large studies increase the chances of a definitive conclusion and provide a better estimate of adverse effects.

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New therapeutic agents in thrombosis and thrombolysis by Jane E Freedman; Joseph Loscalzo

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