By D.R. Buhler and D.J. Reed (Eds.)
This actual quantity, Nitrogen and Phosphorus Solvents, is the second one in a complete and up to date sequence. The advent of latest nitrogen- and phosphorus- containing solvents utilized in has been observed through an explosion of data approximately their houses, toxicity and metabolism. Even a comparatively easy compound corresponding to N-methylformamide undergoes a fancy metabolic transformation in mammals. Such info, and different issues contained during this quantity will provide researchers and scholars with an outstanding details resource on glossy mechanistic toxicology, whereas aiding to supply a legitimate clinical foundation for actual wellbeing and fitness probability assessment.
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In Wistar rats, 14-19% of the 14C was present as 3- and 4-aminocyclohexanols, while in the DA strain rat, aminocyclohexanols accounted for only 1-2% of the activity, and in mouse, <1%. Dose or route of administration did not significantly affect metabolism. When [14C]-cyclohexylamine hydrochloride was administered to pregnant rhesus monkeys by infusion into the antecubital vein, maternal and fetal levels of radioactivity were virtually identical over a period of 6 h (Pitkin et al 1969) indicating that cyclohexylamine freely crosses the hemochorial placenta.
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Nitrogen and Phosphorus Solvents by D.R. Buhler and D.J. Reed (Eds.)