Nitrogen and Phosphorus Solvents - download pdf or read online

By D.R. Buhler and D.J. Reed (Eds.)

ISBN-10: 0444813160

ISBN-13: 9780444813169

ISBN-10: 0444904344

ISBN-13: 9780444904348

This actual quantity, Nitrogen and Phosphorus Solvents, is the second one in a complete and up to date sequence. The advent of latest nitrogen- and phosphorus- containing solvents utilized in has been observed through an explosion of data approximately their houses, toxicity and metabolism. Even a comparatively easy compound corresponding to N-methylformamide undergoes a fancy metabolic transformation in mammals. Such info, and different issues contained during this quantity will provide researchers and scholars with an outstanding details resource on glossy mechanistic toxicology, whereas aiding to supply a legitimate clinical foundation for actual wellbeing and fitness probability assessment.

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In Wistar rats, 14-19% of the 14C was present as 3- and 4-aminocyclohexanols, while in the DA strain rat, aminocyclohexanols accounted for only 1-2% of the activity, and in mouse, <1%. Dose or route of administration did not significantly affect metabolism. When [14C]-cyclohexylamine hydrochloride was administered to pregnant rhesus monkeys by infusion into the antecubital vein, maternal and fetal levels of radioactivity were virtually identical over a period of 6 h (Pitkin et al 1969) indicating that cyclohexylamine freely crosses the hemochorial placenta.

Pharmacol. 28, 1719-1726. Leahy JS, Wakefield M, Taylor T (1967) Urinary excretion of cyclohexylamine following oral administration of sodium cyclamate to man. Fd. Cosmet. Toxicol. 5, 447. Lee IP, Dixon RL (1969) Factors affecting cyclohexylamine lethality in mice. Toxicol. Appl. Pharmacol. 14, 654. Lee IP, Dixon RL (1972) Various factors affecting the lethality of cyclohexylamine. Toxicol. Appl. Pharmacol. 22, 465-473. Legator MS, Palmer KA, Green S, Petersen KW (1969) Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.

289. Academic Press, New York. , p. 211. Thomas, Springfield, IL. Hanzlik PJ (1923) Toxicity and actions of the normal butylamines. / . Pharmacol. Exp. Ther. 20, 435-449. Hazardous Substances Data Bank (HSDB) (1988) National Library of Medicine, Bethesda, MD. Kuwata K, Akiyama E, Yamazake Y, Yamasaki H, Kuge Y, Kiso Y (1983) Trace determination of low molecular weight aliphatic amines in air by gas chromatography. Anal. Chem. 55, 21992201. Larson PS, Schwartz JJ, Finnegan JK, Haag HB (1946) The biochemorphology of nicotine I.

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Nitrogen and Phosphorus Solvents by D.R. Buhler and D.J. Reed (Eds.)


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