By William T. Butler, David T. Denhardt, David T. Denhardt, Ann F. Chambers
Osteopontin (OPN) is a protein that's largely expressed and may most probably have a number of organic services in response to structural transformations of the protein and the neighborhood environments during which it truly is expressed. proof is amassing that OPN performs a job in cells derived from monocytes, together with macrophages and osteoclasts. almost immediately there's robust facts that OPN can turn on the migration and adhesion of many cells in vitro and, as a result, might give a contribution to the buildup of cells at websites of irritation in vivo. the chance exists that OPN does greater than easily mediate the buildup of cells; reviews are wanted that assessment activating or inhibitory signs brought on by means of OPN. moreover, extra stories are required to appreciate OPN's functionality in basic and sickness states.
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Four out of 4 TAL lines appeared to recognize the HER-2/neu: 369–377 peptide, indicating that this represented an immunodominant peptide epitope. , 1998). Antigen-presenting cells that have been either directly transfected with constructs encoding target molecules or infected with recombinant viral constructs have also been used to stimulate tumor-reactive T cells. , 1996). , 1998). A number of studies have been carried out in an attempt to generate responses against peptides derived from the p53 tumor suppressor protein.
A point mutation in this gene resulted in the substitution of an asparagine for an aspartic acid residue at position 5 of the peptide epitope. This residue appeared to represent a T cell contact residue, since binding of this peptide to HLA-B*4403 was unaffected by this alteration. This mutation was expressed in the tumor cell line as well as a fresh tumor sample that was isolated from the autologous patient, but not in over 100 additional tumors that were examined. It is not clear if this mutation has any effect on tumor cells, since the function of this gene product is unknown.
1997). The insert that was isolated by screening a melanoma cDNA library had retained a sequence corresponding to the fourth intron of the gp100 gene. The intronic region, which encoded 35 additional amino acids in the normal open reading frame, was found to encode the peptide epitope. This transcript was expressed at relatively low levels in melanomas, but was also expressed in melanocytes, since an HLA-A24 melanocyte cell line was recognized by this CTL. , 1999). A number of T cell epitopes have also been identified in tyrosinase, a critical enzyme involved in the first steps of melanin synthesis.
Osteopontin by William T. Butler, David T. Denhardt, David T. Denhardt, Ann F. Chambers