By Hoyer, Patricia B
"Today, we're uncovered to an ever-growing variety of chemical substances within the setting and there's an expanding understanding of the consequences of those chemical compounds at the ovaries. As such, the possibility of xenobiotic-induced infertility should be higher understood. also, menopause-associated issues are of growing to be health and wellbeing problem in view of the truth that by means of the 12 months 2025, 19.5% of the inhabitants of the U.S. will be menopause-aged girls. Exploring examine into chemical compounds that experience the aptitude to reason early menopause by way of destroying pre-antral ovarian follicles, this e-book is a vital source for researchers in academia, regulatory corporations, and industry"--Provided through publisher. Read more...
summary: "Today, we're uncovered to an ever-growing variety of chemical substances within the atmosphere and there's an expanding information of the consequences of those chemical compounds at the ovaries. As such, the possibility of xenobiotic-induced infertility should be higher understood. also, menopause-associated issues are of becoming future health quandary in view of the truth that by way of the 12 months 2025, 19.5% of the inhabitants of the U.S. should be menopause-aged girls. Exploring examine into chemical compounds that experience the capability to reason early menopause through destroying pre-antral ovarian follicles, this publication is a vital source for researchers in academia, regulatory companies, and industry"--Provided by way of writer
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Additional info for Ovarian toxicology
Reproduced from Bhattacharya, P. , Toxicol. Appl. , 258, 118, 2012. , Under Review). Taken together, these data demonstrate the involvement of PI3K signaling in regulation of transcription factors or enzymes that are directly involved in ovarian xenobiotic metabolism. Thus, new roles for this signaling pathway are emerging, and since this pathway is amenable to manipulation through chemical means, therapeutic interventions may become possible in the future. 7 CONCLUSION The action of ovarian expressed enzymes is critical in determination of whether a chemical exposure is ovotoxic or not.
1998. Tissue-specific expression of rat sulfotransferase messenger RNAs. Drug Metab Dispos 26:598–604. Environmental Protection Agency. 1985. Health Assessment Document for Tricholoroethylene. Final Report. EPA/600/8-82/006F. Washington, DC: Environmental Protection Agency, Office of Health and Environmental Assessment. Fernandez SM, Keating AF, Christian PJ et al. 2008. Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats. Biol Reprod 79:318–327.
1983a). The metabolism pathway begins with DMBA oxidation to DMBA-3,4-diol by CYP 1B1 and hydrolysis by mEH. , 2004; Shimada and Fujii-Kuriyama, 2004). Early studies determined that bioactivation was also necessary for induction of ovotoxicity by DMBA. DMBA-induced oocyte destruction in vivo was inhibited by treatment with alpha-naphthoflavone (ANF; 10 μg/ovary) (Shiromizu and Mattison, 1985). ANF is an AHR antagonist and thereby prevents activation of a number of metabolism enzymes. Intraovarian injection of mice with DMBA (10 μg/ovary) resulted in oocyte destruction (95%) (Shiromizu and Mattison, 1985).
Ovarian toxicology by Hoyer, Patricia B