The Handbook of Metabonomics and Metabolomics - download pdf or read online

By John C. Lindon, Jeremy K. Nicholson, Elaine Holmes

ISBN-10: 0444528415

ISBN-13: 9780444528414

Molecular biology operates at 3 degrees - genes, proteins and metabolites. This ebook is exclusive in that it presents a entire description of an technique (metabonomics) to characterise the endogenous metabolites in a dwelling process, complementing gene and protein reviews (genomics and proteomics). those "omics" tools shape the foundation for knowing biology at a platforms point. The instruction manual of Metabonomics and Metabolomics goals to be the definitive paintings at the swiftly increasing topics of metabolic profiling, metabolite and biomarker identity, encompassing the fields of metabonomics and metabolomics. It covers the foundations of the topic, the analytical and statistical innovations used and the wide range of purposes. * finished description of an procedure (metabonomics) to characterise the endogenous metabolites in a residing process, complementing gene and protein stories * goals to be the definitive paintings at the quickly increasing matters of metabolic profiling, metabolite and biomarker identity * covers the rules of the topic, the analytical and statistical recommendations used and the wide range of purposes.

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Extra info for The Handbook of Metabonomics and Metabolomics

Example text

D. K. Nicholson, J. H. A. W. S. Plumb. High resolution “ultra performance” liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J. , 4, 591–598 (2005). [56] T. Soga, Y. Ohashi, Y. Ueno, H. Nasaoka, M. Tomita, and T. Nishioka. Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. J. , 2, 488–494 (2003). C. K. D. Wilson. Directly-coupled HPLC-NMR and HPLC-NMRMS in pharmaceutical research and development.

Venema, G. Schaafsma, J. J. van Nesselrooij. A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting. J. Nutrition, 133, 3080–3084 (2003). G. Villas-Boas, J. Hojer-Pedersen, M. Akesson, J. Smedsgaard, and J. Nielsen. Global metabolite analysis of yeast: Evaluation of sample preparation methods. Yeast, 22, 1155–1169 (2005). E. Ippolito, J. J. Jain, K. Moulder, S. R. R. I. Gordon. An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers.

Holmes. High-resolution magic angle spinning 1 H NMR spectroscopic studies on intact rat renal cortex and medulla. Magn. Reson. , 41, 1108–1118 (1999). L. W. N. G. Gonzalez. Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens. , 58, 1825–1832 (1998). [53] J. Yang, G. Xu, Y. Zheng, H. Kong, T. Pang, S. Lv, Q. Yang. Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases.

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The Handbook of Metabonomics and Metabolomics by John C. Lindon, Jeremy K. Nicholson, Elaine Holmes


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