By William MacNee, Adam T. Hill, P. Reid, J. Simpson
A single-volume assessment of the present literature in breathing issues, The 12 months in breathing drugs 2003 identifies and evaluates the papers released some time past eighteen months that experience in all likelihood replaced perform, or that expect possible destiny advancements. It presents readers with a state-of-the-science precis of contemporary learn findings, and their implications for medical perform. The e-book offers a hugely concentrated overview of the present literature, compiled via knowledgeable crew from major facilities within the box. it's a functional and available source that each one medical professionals treating respiration stipulations will locate worthwhile of their day-by-day perform.
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Additional info for The Year in Respiratory Medicine 2003
5 vs 15 years). It was also associated with sputum eosinophils ≥2%, (OR 7. 0). 3–59). Thus, persistent airflow limitation is common in severe asthma and may be the result of uncontrolled eosinophilic airway inflammation. Risk factors for airway remodelling in asthma manifested by a low post-bronchodilator FEV1/vital capacity ratio. Rasmussen F, Taylor R, Flannery EM, et al. Am J Respir Crit Care Med 2002; 165: 1480–8. © Clinical Publishing Services Ltd 40 I · ASTHMA BACKGROUND. The changes associated with low lung function or an accelerated decline of lung function may begin in childhood.
Comment The neutrophil has classically been thought of as the first line in defence against bacterial infections and is not typically associated with asthma. However, there is evidence that neutrophils are present in the airways of asthmatic individuals, particularly in those with more severe disease, and those prone to near-fatal attacks |2–4|. The paper by Little et al. adds further weight to the evidence that neutrophils participate in the asthmatic inflammatory response and suggests that they may play a role in the process of airway wall remodelling and the accelerated decline in lung function seen in some asthmatic individuals.
Am J Respir Crit Care Med 2001; 164:2045–50. Stenius-Aarniaia B, Poussa T, Kvarnstrom J, Gronlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomized controlled study. Br Med J 2000; 320:827–32. Kelly YJ, Brabin BJ, Milligan P, Heaf DP, Reid J, Pearson MG. Maternal asthma, premature birth, and the risk of respiratory morbidity in schoolchildren in Merseyside. Thorax 1995; 50:525–30. Ong TJ, Mehta A, Ogston S, Mukhopadhyay S. Prediction of lung function in the inadequately nourished.
The Year in Respiratory Medicine 2003 by William MacNee, Adam T. Hill, P. Reid, J. Simpson